2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-N16121
    12-Deoxyphorbol 13-isobutyrate 25090-74-8
    12-Deoxyphorbol 13-isobutyrate (ER272) (DPB), a diterpene, is a PKCα activator. 12-Deoxyphorbol 13-isobutyrate can be isolated from Euphorbia resinifera's latex. 12-Deoxyphorbol 13-isobutyrate facilitates neural stem cells (NSCs) proliferation and activation as well as TGFα release in a reaction dependent on PKCα activation. 12-Deoxyphorbol 13-isobutyrate increases cognitive performance and hippocampal neurogenesis in senescence-accelerated mouse-prone (SAMP8) models. 12-Deoxyphorbol 13-isobutyrate can be used for neurodegenerative diseases research.
    12-Deoxyphorbol 13-isobutyrate
  • HY-N16451
    Asperindole E 98%
    Asperindole E is an indole-diterpene alkaloid that can be isolated from the coral-associated fungi Aspergillus candidus. Asperindole E exhibits no significant regulatory activity in the model of primary cultured cortical neuronal hyperexcitation.
    Asperindole E
  • HY-N16452
    Asperindole F 98%
    Asperindole F is an indole-diterpene alkaloid that can be isolated from the coral-associated fungi Aspergillus candidus. Asperindole F exhibits no significant regulatory activity in the model of primary cultured cortical neuronal hyperexcitation.
    Asperindole F
  • HY-N16453
    (+)-Catechin 3-gallate 25615-05-8 98%
    (+)-Catechin 3-gallate is an orally active polyphenolic compound that acts as a non-selective proteasome inhibitor. (+)-Catechin 3-gallate exerts antitumor effects by inducing apoptosis and suppressing inflammatory cytokines. (+)-Catechin 3-gallate is promising for research of cancers (e.g., breast, prostate) and neurodegenerative diseases (e.g., Alzheimer’s).
    (+)-Catechin 3-gallate
  • HY-N16466
    Valerenal 4176-16-3 98%
    Valerenal (Nardal) is a sesquiterpene found in Valeriana officinalis root oil. Valerian root can be used as an herbal sedative which is helpful in the treatment of insomnia.
    Valerenal
  • HY-N16467
    Uncarine F 14019-66-0 98%
    Uncarine F (Speciofiline) is a pentacyclic oxindole alkaloid found in Uncaria tomentosa. Uncaria alkaloids have wide medicinal properties, including neuroprotective, anticancer, and antihypertensive activities. Uncaria alkaloids may stimulate the immune system, relax smooth muscles, dilate blood vessels, and act as a diuretic. Uncarine F can be used for the researches of cancer, immunology, cardiovascular and neurological disease.
    Uncarine F
  • HY-N16524
    Alpinin A 2151847-03-7
    Alpinin A is a diarylheptanoid found in the rhizomes of Alpinia officinarum. Alpinin A can strongly inhibit the aggregation of α-synuclein with inhibition rate of 66% at 10 μM. Alpinin A can be used for the research of neurological disease, such as Parkinson’s disease.
    Alpinin A
  • HY-N16525
    Muramine 2292-20-8
    Muramine is an alkaloid. Muramine can be isolated from the bulbs of Corydalis decumbens. Muramine inhibits spontaneous Ca2+ oscillations. Muramine inhibits neuronal excitability with an IC50 value of 13.5  μM.
    Muramine
  • HY-N16538
    4-(Acetoxymethyl)phenyl glucoside 188290-72-4
    4-(Acetoxymethyl)phenyl glucoside is a type of gastrodin derivative that can cross the blood-brain barrier. 4-(Acetoxymethyl)phenyl glucoside exhibits sedative, anticonvulsant and analgesic effects in mouse models. 4-(Acetoxymethyl)phenyl glucoside can be used for research on senile cardiovascular and cerebrovascular diseases as well as brain nerve disorders.
    4-(Acetoxymethyl)phenyl glucoside
  • HY-N16556
    2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside 73519-16-1 98%
    2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside (Compound 45) is a phenolic compound. 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside can be isolated from Shorea roxburghii. 2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside can be used in the research of Cyclophosphamide (HY-17420)-induced peripheral neuropathy.
    2',4',6'-Trihydroxydihydrochalcone 4'-O-glucoside
  • HY-N16576
    Ethyl lecanorate 2611262-88-3
    Ethyl lecanorate is a main secondary metabolite of Claviceps purpurea. Ethyl lecanorate shows neurotoxic effect with an IC50 of 54 µM on CCF-STTG1 cells. Ethyl lecanorate can be used for neurological disease research.
    Ethyl lecanorate
  • HY-N16648
    sEH-IN-22 2305966-67-8
    sEH-IN-22 (Compound 1) is a soluble epoxide hydrolase (sEH) inhibitor (IC50 = 1.1 μM) found in Rubia philippinensis. sEH-IN-22 exhibits anti-inflammatory, analgesic and blood pressure-regulating effects. sEH-IN-22 can be used for the researches of inflammation, neurological and cardiovascular disease.
    sEH-IN-22
  • HY-N16649
    Clausenalansine B 2365501-63-7
    Clausenalansine B (Compound 2) is a carbazole alkaloid found in the fruits of Clausena lansium. Clausenalansine B exhibits potent neuroprotective effects. Clausenalansine B prevents SH-SY5Y cells death from 6-OHDA (HY-B1081A) with an EC50 of 5.82 μM. Clausenalansine B can be used for the research of neurological disease, such as Parkinson’s disease.
    Clausenalansine B
  • HY-N16655
    1-Hydroxyacorenone 185154-98-7
    1-Hydroxyacorenone is a sesquiterpene compound that can be isolated from Acorus tatarinowii. 1-Hydroxyacorenone can be used for research on Alzheimer's disease.
    1-Hydroxyacorenone
  • HY-N16660
    Tangshenoside V 1050399-39-7
    Tangshenoside V is a phenylpropanoid glucoside found in the roots of Codonopsis tangshen. Tangshenoside V has potential anti-inflammatory, immunomodulatory and mucosal protective effects. Tangshenoside V can be used for the researches of inflammation, immunology and neurological disease.
    Tangshenoside V
  • HY-N16662
    erythro-Anethole glycol 103687-27-0 98%
    erythro-Anethole glycol (Compound 11) is an aromatic diol compound found in Foeniculi Fructus. erythro-Anethole glycol has potential antioxidant activity and can be used for the researches of inflammation, cardiovascular and neurological disease.
    erythro-Anethole glycol
  • HY-N16663
    Plantagiolide C 913263-86-2 98%
    Plantagiolide C is a withanolide found in Tacca plantaginea. Tacca plantaginea has analgesic, antipyretic and anti-inflammatory effects.
    Plantagiolide C
  • HY-N16689
    Oxyphyllenodiol B 363610-32-6
    Oxyphyllenodiol B is an eremophilane-type sesquiterpene compound that can be isolated from the fruits of Alpinia oxyphylla. Oxyphyllenodiol B exerts potential anti-inflammatory activity by inhibiting nitric oxide (NO) production. Alpinia oxyphylla is generally known for its effects against diarrhea and dementia.
    Oxyphyllenodiol B
  • HY-N16715
    Monardic acid A 1607436-76-9
    Monardic acid A is a selective inhibitor of AChE, with an IC50 of 53.1 μM against AChE from electric eel. Monardic acid A shows weak inhibitory activity against human erythrocyte AChE (IC50 >100 μM) and has no significant inhibitory effect on BChE. Monardic acid A reduces acetylcholine breakdown by inhibiting AChE activity, and also exhibits inhibitory activity against histamine release and hyaluronidase, thus exerting anti-inflammatory and neurotransmitter regulatory effects. Monardic acid A can be isolated from lungwort (Pulmonaria officinalis) and thyme (Thymus gobicus), and is mainly used in the development of anti-inflammatory drugs and drugs related to neurodegenerative diseases.
    Monardic acid A
  • HY-N16739
    Circumdatin C 223130-61-8
    Circumdatin C is an alkaloid. Circumdatin C shows inhibitory effects against LPS-stimulated NO production. Circumdatin C inhibits AChE activity with an IC50 value of 13.9 μM. Circumdatin C can be used in the research of Alzheimer's disease.
    Circumdatin C
Cat. No. Product Name / Synonyms Application Reactivity